In the same year, William Stewart Halsted from Johns Hopkins Hospital performed the first successful resection for ampullary cancer by excising portions of the duodenum and the pancreas. The first reported attempt at a pancreaticoduodenectomy was performed in 1898 by the Italian surgeon Alessandro Codivilla for a tumor involving the head of the pancreas however, the patient did not survive the postoperative period. Some landmarks in the history of pancreatic surgery deserve to be mentioned. The history of pancreatic surgery is fairly recent and involves a combination of brave surgical pioneers, the development of surgical anesthesia and modern aseptic techniques. The next important advancement in our understanding of pancreatic cancer did not come until 1858, when Jacob Mendez Da Costa revisited Morgagni's original work and also described the first microscopic diagnosis of adenocarcinoma, manifesting pancreatic cancer as a true disease entity.
However, the lack of a microscopic evaluation makes the true diagnosis of ductal adenocarcinoma uncertain. The first known description of pancreatic cancer is attributed to Giovanni Battista Morgagni in his 1761 publication ‘de Sedibus Et Causis Morborum Per Anatomen Indagatis Libri Quinque’.
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